Welcome! I am a Crohn's colitis survivor, fighter and persistant proactive patient that will not stop the search.. 4 THE CURE! Meanwhile, I will utilize this blog to educate, support and provide up to date, valuable information about Crohn's Disease, IBD, IBS and many other chronic conditions.
The part of this picture that should jump out at you is the statistic on the bottom left. citation # 3
92% !!!....... this is madness! This isn't new news people. So why doesn't anyone know about MAP and it's relation to Crohn's? I'm not talking about lay persons, but people in the profession of helping people get better who are living with this disease. They don't acknowledge it. The medical community flat out ignores the science and the 30 years or more of research that exists. People need to take charge of their life and health and start fighting to know something. Ask questions and demand an answer is where I'd start.
Click link below to view image larger from original source:
Informative 3 min. YouTube video to raise awareness about the Crohn's-MAP bacteria connection. How humans are exposed and vulnerable to MAP - There are now ways to test for MAP. I also posted the links that were provided on the YouTube page under the video for further reading/info.
- The Crohn’s MAP Vaccine A modern therapeutic Vaccine against MAP has been created. Preliminary studies in animals have shown it to be safe and effective. Next, a trial in humans is needed to take the vaccine from lab to clinic. Professor John Hermon-Taylor, King's College London http://crohnsmapvaccine.com
That would be cool. Getting treated based on needs that addresses the missing component. I'll be positive and not bitch about the fact that they aren't looking to zoom up on what the cause is that is changing the cells in the first place. Something is causing them to respond to certain factors a certain way. That's a post for another day. This study was positive though. Maybe this can lead to treatments that can improve the quality of life in people that suffer from IBD/gastrointestinal disturbances. We can only hope that treatments will be better and safer. So, Washington University researchers used biopsy cells, taken from patients during a routine endoscopy to study if epithelial cells could be grown in the lab if therapeutic conditions were provided. According to the article, cells were obtained and placed in "a high concentration of conditioned media containing the factors critical for growth (Wnt3a, R-spondin and Noggin)". Within 2 weeks, the result from these conditions were positive. They showed that epithelial cells formed "functional, polarised monolayers covered by a secreted mucus layer when grown on Transwell membranes". They also exposed the cells to bacteria (e. coli) to see how they would respond when exposed to harmful bacteria changes. The results were favorable.
For this to be possible, the team explained in the abstract of their study that epithelial cells must be enhanced so that biopsies from patients can be used to generate cell lines (which are populations of cells in culture with the same genetic makeup) in a short time frame, so that the analysis can be made accurately.
In two weeks, researchers were able to create 65 human gastrointestinal epithelial cell lines from biopsies of 47 patients, taken during routine endoscopic screening procedures. They used a high concentration of conditioned media containing the factors critical for growth, which resulted in a rapid expansion of the proliferative stem and progenitor cells. In addition, the team used a combination of lower conditioned media concentration and Notch inhibition to differentiate these cells for further research.
Results showed that under differentiation conditions, intestinal epithelial spheroids developed mature epithelial lineages in specific regions. These cells formed functional, polarized monolayers covered by a secreted mucus layer when grown on Transwell membranes.
After this process, researchers conducted experiments to determine how the cells interacted with bacterial pathogens like Escherichia coli. They found the cells also demonstrated novel adherence phenotypes with various strains of pathogenic Escherichia coli.
Ultimately, these findings can help testing of new drug targets, as well as developing vaccines. Furthermore, they will play a crucial role in understanding how human cells interact with beneficial and harmful microbes, researchers believe.
Link to the abstract journal article in Gut - http://gut.bmj.com/content/early/2014/07/09/gutjnl-2013-306651.abstract?sid=79c1ef19-7ade-4f0b-99cf-aadfe542fd76Gutdoi:10.1136/gutjnl-2013-306651
For those of you that are not fond of hoses and tubes getting inserted up your butt, there's another option, a less invasive method, for colorectal health screening. I have needed scopes since I was 16 or 17, so the traditional scope doesn't bother me. Some people that I know won't even consider getting screened because of embarrassment or because they think they are fine. People that neglect this kind of screening are really neglecting their health and chancing it. Colon cancer doesn't have to be fatal. Screenings are the only way to catch something abnormal. Because there are no symptoms until it's too late, the screening is the only way to know if something is brewing and needs to be treated or addressed. Yay!!! for more patient options! Now pick one and be healthy. Gastroenterology & Endoscopy News - FDA Approves New Test for Colorectal Cancer:
FDA Approves New Test for Colorectal Cancer
by GEN Staff
The FDA has approved a new screening test that detects the presence of blood and genetic material linked to colorectal cancer (CRC).
The test, called Cologuard, is the first to combine fecal blood and DNA testing in a single screening. Cologuard been shown to find 92% of cancers, and 69% of polyps with high-grade dysplasia, in patients at average risk for CRC, according to Exact Sciences, which makes the test. Results from the pivotal trial were published earlier this year in The New England Journal of Medicine. The study found that although the new test detected many more cancers than fecal immunochemical testing, it had more false-positive results.
“The robustly conducted research as part of this FDA approval process has proven that this noninvasive test is highly sensitive in detecting both early-stage colorectal cancer and the most advanced precancerous polyps most likely to develop into cancer,” said David Ahlquist, MD, a gastroenterologist at Mayo Clinic, in Rochester, Minn., who helped invent the test, in a statement. “The test is designed for high accuracy, ease of patient use and wide accessibility. We hope that it will make a difference and save many lives.”
DNA testing for CRC has not been endorsed by bodies such as the U.S. Preventive Services Task Force, whose recommendations influence clinical practice. However, the Centers for Medicare & Medicaid Services has proposed covering Cologuard testing every three years for Medicare beneficiaries.
If you have Crohn's UC IBS or any digestive issues, you probably don't absorb all the nutrients from the food you eat. You have to supplement with a good product that will make up for what you lose in your food. Also, if you have to adhere to a strict diet, limited diet, you may not even consume some of the foods that nourish and provide you with the needed vitamins and minerals that you need to keep your body functioning to the best of it's ability.
Garden of Life is by far, one of the best supplement/vitamin/herb companies out there. They are one of the few brands that provide ORGANIC supplements. Have you noticed that it's very rare to find good vitamins that are organic? I never used to look for organic until I refuse to put anything that isn't organic into my body. I'm posting what I take from them that works great and am able to tolerate. My body is sensitive to supplements, so finding a brand that my body can handle is a process of trial and error. Hope you find this helpful :)
( Everything I have posted here can be found at www.gardenoflife.com )
The Vitamin Code - Healthy Blood: I need iron, but have never been able to tolerate oral iron at all. This doesn't irritate my digestive system or give me any problems. Works great.
Hello to everyone who reads what I post on here. I hope you've found something helpful in the information and topics that I choose to highlight in my posts. I took a bit of a break from researching my ass off for the past few months, but I'm back at it again. I'll never stop learning about this disease, as I am empowered by the things I know about it. It tends to make me feel more in control as well. My new posts are not going to be posted here, however. Maybe I will import the new entry onto this Blogger/blogspot blog for a few months or something, but I need to switch & want to switch. The rss code has an error somewhere. I have tried to fix it, with no success and I'm done. People that 'subscribe' to a post or new posts, will not get the notification because the code is f'd up. All the places that each blog entry is supposed to go to when I publish the entry, doesn't go anywhere. It's annoying. I haven't figured out where exactly I will move my blog to, but I'll let you guys know where when I get it going. Have any suggestions for good blog platforms?? Or are there any blogging sites that you tend to prefer more than others? let me know....
Yes, FMT's work for people with c-diff. There are numerous articles that will tell you so. 90% of the patients get better after FMT treatments, versus something like 30% recovery rate with the old school antibiotic treatment, which is just plain bad for treating something like this. If the body has any healthy bacteria left, the antibiotics will be sure to kill it all - Not good. You actually want to do the opposite of kill it and instead, replenish the body with healthy bacteria. That's exactly what FMT's do and people get well.
This procedure should be the first method of treatment rather than the antibiotic method. I'm not sure if the US FDA has changed their views on FMT's but with this to consider : "500,000 cases of CDI in the United States annually, with health care costs ranging from $1.3 billion to $3.4 billion." Maybe the costs could be significantly reduced by going with the more effective treatment 1st. Wouldn't that be the more logical and humane thing to do anyway?
Fecal microbiota transplantation—the process of delivering stool bacteria from a healthy donor to a patient suffering from intestinal infection with the bacterium Clostridium difficile—works by restoring healthy bacteria and functioning to the recipient's gut, according to a study published this week inmBio, the online open-access journal of the American Society for Microbiology.
A writer for Psychology Today, contributes the following article (and 2 more that I will post after this article) pertaining to something that I have read up on and firmly believe is the culprit to Crohn's disease. Everyone should read this information and remember it. I think a lot of people have been made hopeless or skeptical in regards to Crohn's disease because people are told so many things that contradict that there will ever be a cure. Doctor's have been telling people for decades now that there will never be a cure. It's a new day people, get out of the rut of thinking in the past and open your mind to new developements and discoveries. It's worth it and I am super duper hopeful.
Through luck, hard work, good fortune, perseverance, and wonderful doctors, I seem to be one of the few people in the world who can claim to be “cured” of Crohn’s Disease. I’ve told this story before, in several places, but I feel a need to get the information out to a more general audience, even though this is not a psychology story but a medical and scientific one. In September, 2005, I wrote a small article for the PCC SoundConsumer, a very small newspaper published by a local Seattle natural foods grocery store, about my experience with Crohn’s Disease.http://www.pccnaturalmarkets.com/sc/0509/sc0509-hw-crohns.htmFor some reason, that little article went viral, and to this day I receive letters from people from all over the world asking for information about Crohn’s Disease and its probable connection with a specific microbe, mycobacterium avium subspecies paratuberculosis (MAP). I told the story again in a scientific journal, the Paratuberculosis Newsletter,http://www.paratuberculosis.info/web/images/newsletters/2012q2.pdfBut that journal is not highly visible. Since 8 years has gone by, and I have much more information now, I am going to put this on Psychology Today, for the benefit of all of those who suffer from Crohn’s or who love people who suffer from Crohn’s. I will have to tell this story in several segments, since Psych Today restricts individual posts to about 800 words. Please bear with me. I will be providing a lot of information, references, and information that is crucial to individual and public health.Single case reports are no longer the fashion in modern medicine. We all know that an n of 1 plus 1 plus 1 plus 1 ad infinitum equals nothing in terms of proving causality in “evidence based medicine”. Proving anything in the case of Crohn’s Disease is difficult. See this excellent review of this situation, Causality and gastrointestinal infections: Koch, Hill, and Crohn’s by Anne-Marie Lowe, Cedric P Yansouni, and Marcel A Behr, Lancet Infect Dis 2008:8: 720–26. You must understand that for scientists today, a single case report is virtually meaningless. However, my victory over Crohn’s Disease doesn’t prove anything by itself, but I think that it matters insofar as it suggests the desirability of pursuing a more detailed scientific inquiry. Furthermore, there are hundreds of thousands of people with Crohn’s, many of them children, who are being treated under a different paradigm, and with variable success. Moreover, I think many of those people got sick because they consumed contaminated food products without knowing it, sometimes years before the disease manifested itself. I think there is better way to treat Crohn’s, and better yet, to prevent it. In brief, I think I was “cured” of Crohn’s Disease with antibiotics directed at the eradication of Mycobacterium avium subspecies paratuberculosis.Background: MAP is a small bacteria in the same family as leprosy and tuberculosis. In 1894, two veterinarians, Dr. H.A. Johne and Dr. L. Frothingham, identified this organism in a cow with weight loss and poor milk production in Germany. It is an acid-fast bacterium, like TB and leprosy, but has other properties as well. The best place to read about MAP is on the web sitewww.johnes.org Farmers rapidly learned that their cows could develop either bovine TB or what came to be known as Johne’s Disease. Both were serious and expensive for the farmers. However, for various reasons, everyone agreed that tuberculosis could be transmitted from cows to people, and many public health measures were put into place to stop bovine TB. However, to this day, the USDA and the IOE, the World Organization for Animal Healthhttp://www.oie.int/deny that MAP is a “zoonotic disease”, a disease that can be transmitted from animals to people. The ostensible reasons for this are that MAP cannot be visualized in human tissues with ordinary microscopes (while it is easy to see MAP in animal specimens); PCR studies and other DNA fingerprinting technologies yield ambiguous results; and nobody dares to try the experiment to prove Koch’s postulates, which would be to grow human MAP in culture, and then feed those germs to human infants. That would be immoral and ridiculous. For various reasons, scientists dispute the claim that MAP causes Crohn’s Disease because Koch’s postulates have not been fulfilled, even though nobody has ever grown M. Leprae (the germ that causes leprosy) in culture. It has to be grown in the foot pads of armadillos…. Koch’s postulates are not applied to viruses, prions, or other pathogens. Even though MAP comes very close to meeting Koch’s postulates, its pathogenicity is disputed. (There was even an experiment in the 1980s in which MAP was grown from human biopsy specimens, and then fed to baby goats. The goats got Johne’s Disease. But it was a small n…) As a result, animals that test positive for MAP are not culled and eliminated from human food products. They can be sold for meat, into the food supply. Moreover, viable MAP can be cultured from milk, including pastuerized milk, around the world. MAP is a very stubborn bacteria, resistant to heat and chlorine. It thrives on biofilms, and has a persistent spore that can last for years. The incidence of Crohn’s Disease in the world has grown in proportion to the use of dairy products. For example, Japan had little Crohn’s 100 years ago, and now it is becoming a significant problem. When you go to the grocery store and consider buying raw milk products, remember that MAP is endemic to cows, sheep, and goats, and roughly 1% of pasteurized milk in the US contains viable MAP.