Welcome! I am a Crohn's colitis survivor, fighter and persistant proactive patient that will not stop the search.. 4 THE CURE! Meanwhile, I will utilize this blog to educate, support and provide up to date, valuable information about Crohn's Disease, IBD, IBS and many other chronic conditions.
The part of this picture that should jump out at you is the statistic on the bottom left. citation # 3
92% !!!....... this is madness! This isn't new news people. So why doesn't anyone know about MAP and it's relation to Crohn's? I'm not talking about lay persons, but people in the profession of helping people get better who are living with this disease. They don't acknowledge it. The medical community flat out ignores the science and the 30 years or more of research that exists. People need to take charge of their life and health and start fighting to know something. Ask questions and demand an answer is where I'd start.
Click link below to view image larger from original source:
Informative 3 min. YouTube video to raise awareness about the Crohn's-MAP bacteria connection. How humans are exposed and vulnerable to MAP - There are now ways to test for MAP. I also posted the links that were provided on the YouTube page under the video for further reading/info.
- The Crohn’s MAP Vaccine A modern therapeutic Vaccine against MAP has been created. Preliminary studies in animals have shown it to be safe and effective. Next, a trial in humans is needed to take the vaccine from lab to clinic. Professor John Hermon-Taylor, King's College London http://crohnsmapvaccine.com
That would be cool. Getting treated based on needs that addresses the missing component. I'll be positive and not bitch about the fact that they aren't looking to zoom up on what the cause is that is changing the cells in the first place. Something is causing them to respond to certain factors a certain way. That's a post for another day. This study was positive though. Maybe this can lead to treatments that can improve the quality of life in people that suffer from IBD/gastrointestinal disturbances. We can only hope that treatments will be better and safer. So, Washington University researchers used biopsy cells, taken from patients during a routine endoscopy to study if epithelial cells could be grown in the lab if therapeutic conditions were provided. According to the article, cells were obtained and placed in "a high concentration of conditioned media containing the factors critical for growth (Wnt3a, R-spondin and Noggin)". Within 2 weeks, the result from these conditions were positive. They showed that epithelial cells formed "functional, polarised monolayers covered by a secreted mucus layer when grown on Transwell membranes". They also exposed the cells to bacteria (e. coli) to see how they would respond when exposed to harmful bacteria changes. The results were favorable.
For this to be possible, the team explained in the abstract of their study that epithelial cells must be enhanced so that biopsies from patients can be used to generate cell lines (which are populations of cells in culture with the same genetic makeup) in a short time frame, so that the analysis can be made accurately.
In two weeks, researchers were able to create 65 human gastrointestinal epithelial cell lines from biopsies of 47 patients, taken during routine endoscopic screening procedures. They used a high concentration of conditioned media containing the factors critical for growth, which resulted in a rapid expansion of the proliferative stem and progenitor cells. In addition, the team used a combination of lower conditioned media concentration and Notch inhibition to differentiate these cells for further research.
Results showed that under differentiation conditions, intestinal epithelial spheroids developed mature epithelial lineages in specific regions. These cells formed functional, polarized monolayers covered by a secreted mucus layer when grown on Transwell membranes.
After this process, researchers conducted experiments to determine how the cells interacted with bacterial pathogens like Escherichia coli. They found the cells also demonstrated novel adherence phenotypes with various strains of pathogenic Escherichia coli.
Ultimately, these findings can help testing of new drug targets, as well as developing vaccines. Furthermore, they will play a crucial role in understanding how human cells interact with beneficial and harmful microbes, researchers believe.
Link to the abstract journal article in Gut - http://gut.bmj.com/content/early/2014/07/09/gutjnl-2013-306651.abstract?sid=79c1ef19-7ade-4f0b-99cf-aadfe542fd76Gutdoi:10.1136/gutjnl-2013-306651
For those of you that are not fond of hoses and tubes getting inserted up your butt, there's another option, a less invasive method, for colorectal health screening. I have needed scopes since I was 16 or 17, so the traditional scope doesn't bother me. Some people that I know won't even consider getting screened because of embarrassment or because they think they are fine. People that neglect this kind of screening are really neglecting their health and chancing it. Colon cancer doesn't have to be fatal. Screenings are the only way to catch something abnormal. Because there are no symptoms until it's too late, the screening is the only way to know if something is brewing and needs to be treated or addressed. Yay!!! for more patient options! Now pick one and be healthy. Gastroenterology & Endoscopy News - FDA Approves New Test for Colorectal Cancer:
FDA Approves New Test for Colorectal Cancer
by GEN Staff
The FDA has approved a new screening test that detects the presence of blood and genetic material linked to colorectal cancer (CRC).
The test, called Cologuard, is the first to combine fecal blood and DNA testing in a single screening. Cologuard been shown to find 92% of cancers, and 69% of polyps with high-grade dysplasia, in patients at average risk for CRC, according to Exact Sciences, which makes the test. Results from the pivotal trial were published earlier this year in The New England Journal of Medicine. The study found that although the new test detected many more cancers than fecal immunochemical testing, it had more false-positive results.
“The robustly conducted research as part of this FDA approval process has proven that this noninvasive test is highly sensitive in detecting both early-stage colorectal cancer and the most advanced precancerous polyps most likely to develop into cancer,” said David Ahlquist, MD, a gastroenterologist at Mayo Clinic, in Rochester, Minn., who helped invent the test, in a statement. “The test is designed for high accuracy, ease of patient use and wide accessibility. We hope that it will make a difference and save many lives.”
DNA testing for CRC has not been endorsed by bodies such as the U.S. Preventive Services Task Force, whose recommendations influence clinical practice. However, the Centers for Medicare & Medicaid Services has proposed covering Cologuard testing every three years for Medicare beneficiaries.
If you have Crohn's UC IBS or any digestive issues, you probably don't absorb all the nutrients from the food you eat. You have to supplement with a good product that will make up for what you lose in your food. Also, if you have to adhere to a strict diet, limited diet, you may not even consume some of the foods that nourish and provide you with the needed vitamins and minerals that you need to keep your body functioning to the best of it's ability.
Garden of Life is by far, one of the best supplement/vitamin/herb companies out there. They are one of the few brands that provide ORGANIC supplements. Have you noticed that it's very rare to find good vitamins that are organic? I never used to look for organic until I refuse to put anything that isn't organic into my body. I'm posting what I take from them that works great and am able to tolerate. My body is sensitive to supplements, so finding a brand that my body can handle is a process of trial and error. Hope you find this helpful :)
( Everything I have posted here can be found at www.gardenoflife.com )
The Vitamin Code - Healthy Blood: I need iron, but have never been able to tolerate oral iron at all. This doesn't irritate my digestive system or give me any problems. Works great.