Saturday, January 31, 2015

HSP70 Could Fix Gene Mutations of NOD2 in People w/ Crohn's Disease

I have all these drafts that I never published at the time that I am going to post now.  My focus and concentration is not on the management of symptoms to quiet Crohn's anymore.  There's too much scientific data that suggests that Crohn's is caused by a bacteria in people that are immune deficient (can't fight off the pathogen and kill it the way normal immune systems do - that's why some people get Crohn's and others remain healthy).
My goal is to be well and have health again. I do understand that everyones approach to handling their disease is unique to the individual, so if I can provide anything that can help them, I will do that.
Happy Saturday.. Yay, it's sunny!

Researchers have uncovered a protein that stabilizes Crohn's disease gene
Researchers say they have identified a protein that stabilizes another protein involved in Crohn's disease. University of Delaware researchers discovered how certain proteins can prevent gut bacteria can trigger an abnormal immune response to lead to inflammation associated with Crohn's and other inflammatory bowel disorders.
New target for treating Crohn's disease
Past research has focused on the role of gut bacteria as a contributor to Crohn's disease. The new research conducted by Catherine Leimkuhler Grimes, assistant professor of chemistry and biochemistry at UD, and Vishnu Mohanan, doctoral student in biological sciences focused on mutation of a gene called NOD2 — nucleotide-binding oligomerization domain containing protein 2 - that is strongly associated with Crohn's disease.
Mohanan discovered HSP70 that stands for "heat shock protein 70" plays a role in helping the body attack "bad" gut bacteria, which essentially "fixes" mutations of NOD2.
HSP70 is referenced as a chaperone molecule that helps proteins maintain their three dimensional shape.
According to a press release, "..we stumbled on this chaperone molecule," says Mohanan, who was the lead author of article.published in the July 4, 2014 Journal of Biological Chemistry.''