Sunday, November 18, 2012

*Viable New Treatment* Elafin Introduced w/ Probiotic=Reduces Inflammation, Supporting Intestinal Cell Healing.

This sounds good!   

Pretty promising treatment in the clinical phase of testing sounds like a safe and effective way to restore balance to the intestinal flora, resulting in cell healing and reduced inflammation in inflammatory bowel disease patients.  I'd like to try this kind of treatment.  

Published Research: found in Science Translational Medicine Review

Fighting Intestinal Inflammation With New Bacteria

This protection is provided by a human protein, Elafin, which is artificially introduced into dairy produce bacteria (Lactococcus lacti andLactobacillus casei). In time, this discovery could be useful for individuals suffering from chronic inflammatory diseases such as Crohn's disease or ulcerative colitis. The results of this research were published in the Science Translational Medicine review.

In France, nearly 200,000 individuals suffer from chronic inflammatory bowel disease, known as IBD, (specifically Crohn's disease and ulcerative colitis). The occurrence rate of this type of disease continues to rise (8,000 new cases diagnosed per year). During inflammatory outbreaks, IBDs are chiefly characterised by abdominal pain, frequentdiarrhoea (sometimes with bleeding) or even disorders in the anal area (fissure, abscesses). These symptoms mean that taboos are associated with these diseases.

Different avenues are being explored to explain the origin of IBDs, including the role of genetic or environmental factors. The intestinal flora seems to play an important role in the outbreak of inflammation, although little is known about it. Identifying an effective treatment is also at the heart of the investigations.

Researchers are focussing on a human protein, known for its anti-inflammatory proprieties: Elafin. Although this protein is found naturally in the intestine to protect it against attacks, it disappears in patients suffering from IBDs.

Their hypothesis? Administering Elafin directly into the intestine could protect against inflammatory attacks and restore intestinal equilibrium and its functions.

Using non-pathogenic bacteria found naturally in the intestine and food, scientists from Inserm and Inra have designed modified bacteria to produce Elafin. To this end, the human Elafin gene, isolated in collaboration with a team from the Institut Pasteau, was introduced in Lactococcus lacti and Lactobacillus casei, two food-grade bacteria found in dairy products.

Results in mice...

When administered orally to mice, the human Elafin-producing bacteria are found a few hours later on the surface of the intestine where they deliver the anti-inflammatory protein. In different mice models of chronic or acute intestinal inflammation, oral treatment using these Elafin-producing bacteria provided significant protection of the intestine and decreased inflammatory symptoms.

... and in humans

Elafin expressed by these bacteria also protects cultured human intestinal cell lines from inflammatory outbreaks similar to those observed in chronic inflammatory bowel diseases. Elafin produced in this way restores the equilibrium of intestinal mucus by reducing inflammation and accelerating cell healing processes.

Potential clinical applications

These results may result in a clinical application where Elafin would be administered to patients suffering from IBDs using beneficial bacteria (probiotic), which are already commonly found in food (yoghurt, cheese), thus protecting the patients from inflammatory symptoms. According to the researchers "This kind of secure treatment could even be used over the long-term, to treat inflammatory diseases." 

n.p. (2012, November 8). "Fighting Intestinal Inflammation With New Bacteria." Medical News Today. Retrieved from

This research is protected by a patent and an exclusive licence assigned to an industrial partner, managed by Inserm Transfert.
Food-grade bacteria expressing Elafin protect against inflammation and restore colon homeostasis.
Motta, J.P*1, 2, 3, Bermúdez-Humarán, L.G.*4, Deraison, C.1, 2, 3, Martin, L.1, 2, 3, Rolland, C.1, 2, 3, Rousset, P.1, 2, 3, Boue, J1, 2, 3., Dietrich G1, 2, 3., Chapman, K.5, Kharrat, P.4, Vinel, J.P.3, 6, Alric, L. 3, 6, Mas, E.1, 2, 3, 7, Sallenave, J.M.8,9,10, Langella, P.* 4, Vergnolle, N.* 1, 2, 3, 5
* Equal contribution
INSERM (Institut national de la santé et de la recherche médicale)

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