In my opinion the test gives both the patient and the doctor a more certain answer as to what the disease is and the ability to choose the best treatments for the specific illness.
- Marla Dubinsky, MD, director of the Pediatric Inflammatory Bowel Disease Center at Cedars-Sinai Medical Center in Los Angeles, believes the tool can be used when a definitive IBD, CD or UC diagnosis remains hazy, despite clinical, endoscopic and histologic findings.
- The new instrument also tests for genetic markers—including ATG16L1, NKX2.3, STAT3 and ECM1—that are linked to defective bacterial handling or autophagy, dysregulated signaling pathways and impaired epithelial barrier function in IBD.
- According to Dr. Dubinsky, one potential application of the test would be to help clinicians who are considering a referral for colectomy to determine more confidently whether the patient has a “CD-like” or “UC-like” phenotype.
Gastroenterology & Endoscopy News - Novel Test Identifies IBD Subtypes:
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