Sunday, May 15, 2011
Mycobacterium avium subspecies paratuberculosis (MAP) "suspected as a causative agent in Crohn's disease"
Hmmmmm... interesting. My friend happened to stumble upon this on Wikipedia when she was reading about milk pasteurization (totally unrelated to Crohn's). I thought that milk is supposed to do our body good.. Well, that's what they used to say. And if this is a possible cause of Crohn's disease (because remember no one knows the cause of Crohn's), why are they not doing more research to find out for sure.
Maybe this explains why children as young as 3 or 4 years old get Crohn's Disease. The whole time they are sippin on their yummy warm milk in their bottle or sippy cup, they're possibly swallowing some MAP, which is a stubborn, resistant bastard. That could explain where Crohn's gets it's stubbornness from.
Just thought this was something to think about. Feel free to leave opinions :)
MAP causes Johne's disease in cattle and other ruminants, and it has long been suspected as a causative agent in Crohn's disease in humans; this connection is controversial.
Recent studies have shown that MAP present in milk can survive pasteurization, which has raised human health concerns due to the widespread nature of MAP in modern dairy herds. MAP survival during pasteurization is dependent on the D72C-value of the strains present and their concentration in milk. It is heat resistant and is capable of sequestering itself inside white blood cells, which may contribute to its persistence in milk. It has also been reported to survive chlorination in municipal water supplies.
Even though MAP is hardy, it is slow growing and fastidious, which means it is difficult to culture. Many negative studies for MAP presence in living tissue, food, and water have used culture methods to determine whether the bacteria are present. Due to recent advances in our knowledge of the bacterium, some or all of these studies may need to be re-evaluated on the basis of culture methodology.
MAP infections, like with most mycobacteria, are difficult to treat. It is not susceptible to antituberculosis drugs (which can generally kill Mycobacterium tuberculosis), but can only be treated with a combination of antibioticssuch as rifabutin and a macrolide such as clarithromycin. Treatment regimens can last years.
MAP is recognized as a multi-host mycobacterial pathogen with a proven specific ability to initiate and maintain systemic infection and chronic inflammation of the intestine of a range of histopathological types in many animal species, including primates.
On the assumption that MAP is a causative agent in Crohn's disease, the Australian biotechnology company Giaconda is seeking to commercialize a combination of rifabutin, clarithromycin, and clofazimine as a potential drug therapy, called Myoconda, for Crohn's. As of April 2007, Giaconda received United States FDA IND approval for a new Phase 2/3 trial.
MAP has been found in larger numbers within the intestines of Crohn's disease patients than those with ulcerative colitis and healthy controls.