I get so excited when I read about this possible treatment, RHB-104, for Crohn's! I've been watching this drug for over a year now. This is a treatment that if approved by the FDA, I will be jumping on it as soon as it becomes available. No doubt! This is the kind of treatment we need. Everything else just treats symptoms.
So, why is this so exciting? If you read current research about what causes Crohn's disease, you will see that researchers are leaning away from considering Crohn's disease an autoimmune condition. They have found that there is an underlying cause for the immune response to activate. Crohn's is said to be caused by a combo of 3 factors - Immune system abnormalities, environmental influences and bacteria. I just wiki'd Crohn's disease and this is what is said about what is believed to be the cause - "Crohn's disease is caused by interactions between environmental, immunological and bacterial factors in genetically susceptible individuals. This results in a chronic inflammatory disorder, in which the body's immune system attacks the gastrointestinal tract possibly directed at microbial antigens. While Crohn's is an immune related disease, it does not appear to be an autoimmune disease (in that the immune system is not being triggered by the body itself)."
What this means is that people that have Crohn's disease do not have the immune system capabilities to destroy a form of bacteria that have been introduced into the body at some point in time. As research has indicated, a large number of people with Crohn's disease happen to have the MAP bacteria in their body somewhere. The exact location of the bacteria is not known at this time. Who cares where it is, as long as a treatment is available that will destroy it is my opinion.
See why this makes me super hopeful? If Crohn's is caused by this MAP bacteria & if this new combination antibiotic eradicates the MAP bacteria from people with Crohn's disease, this could be the answer to the Crohn's disease epidemic! Can someone say CURE :)
Wouldn't that be glorious?
Clinical trial for a new antibiotic therapy for Crohn’s treatment started:
RedHill Biopharma to initiate phase III trial of RHB 104 in Crohn's disease patients