TH17 Cells - The Role They Play In The Autoimmune Response In IBD - New Discoveries

Interesting information to know.  This link has several parts that discuss and explain the function of TH17 Cells ( The cells that are shown to effect both innate and adaptive immune responses by the release of regulatory cytokines) and the impact they have on Inflammatory Bowel DIsease.

Abstract is below.  To read entire Journal entry, click the link. 

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Interactions With Predisposing Factors in the Immunopathogenesis of Inflammatory Bowel Disease Expert Review of Clinical Immunology, 2012-02-01   
From Expert Review of Clinical ImmunologyTh17 Cells
Th17 Cells: Interactions With Predisposing Factors in the Immunopathogenesis of Inflammatory Bowel Disease CMEAli Raza, MD; Wajeeha Yousaf, MD; Ralph Giannella, MD; Mohamed Tarek Shata, MD, PhD
CME Released: 01/30/2012; Valid for credit through 01/30/2013       

ABSTRACT

Inflammatory bowel disease (IBD) is a chronic inflammatory state of the GI tract of unknown etiology. Classically, tissue injury in IBD is thought to be primarily mediated by Th1 cells in Crohn’s disease or Th2 cells in ulcerative colitis. The discoveries of new subsets of T-helper cells, especially Th17 cells, have revolutionized our understanding of the disease immunopathology. Th17 cells seem to affect both innate and adaptive immune responses by the release of regulatory cytokines. Understanding the role of Th17 cells in IBD pathogenesis and targeting their regulatory cytokines may provide potential therapeutic approaches for the treatment of IBD in the future.

 

Faculty and Disclosures